› 6k4n

Electron Microscopy
9.8Å resolution

Cryo-EM structure of p300

Released:
DOI: 10.2210/pdb6k4n/pdb
PDB entry 6k4n coloured by chain, front view.
PDB entry 6k4n coloured by chain, side view.
PDB entry 6k4n coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Tumor Suppressor p53-Mediated Structural Reorganization of the Transcriptional Coactivator p300.
Ghosh R, Kaypee S, Shasmal M, Kundu TK, Roy S, Sengupta J
Biochemistry 58 3434-3443 (2019)
PMID: 31314496
Related structures: EMD-6792

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170794 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone acetyltransferase p300 Chain: A
Molecule details ›
Chain: A
Length: 619 amino acids
Theoretical weight: 72.1 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q09472 (Residues: 1046-1664; Coverage: 26%)
Gene names: EP300, P300
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 9.8Å
Relevant EMDB volumes: EMD-6792
Expression system: Spodoptera frugiperda

Quick links

Citations

2 review citations

Regulating tumor suppressor genes: post-translational modifications.
Chen et al. (2020)
1 more