6k7l

Electron Microscopy
2.83Å resolution

Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E2P state class2)

Released:
Source organism: Homo sapiens
Related structures: EMD-9939

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-192631 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Phospholipid-transporting ATPase IA Chain: A
Molecule details ›
Chain: A
Length: 1154 amino acids
Theoretical weight: 130.54 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9Y2Q0 (Residues: 1-1164; Coverage: 99%)
  • Best match: Q9Y2Q0-3 (Residues: 1-1149)
Gene names: ATP8A1, ATPIA
Sequence domains:
Cell cycle control protein 50A Chain: C
Molecule details ›
Chain: C
Length: 361 amino acids
Theoretical weight: 40.73 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9NV96 (Residues: 1-361; Coverage: 100%)
Gene names: C6orf67, CDC50A, TMEM30A
Sequence domains: LEM3 (ligand-effect modulator 3) family / CDC50 family

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, MAN
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.83Å
Relevant EMDB volumes: EMD-9939
Expression system: Homo sapiens