6k7x

Electron Microscopy
3.27Å resolution

Human MCU-EMRE complex

Released:
Source organism: Homo sapiens
Related structures: EMD-9944

Function and Biology Details

Biochemical function:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
hetero hexadecamer (preferred)
PDBe Complex ID:
PDB-CPX-185508 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Calcium uniporter protein, mitochondrial Chains: A, B, C, D, K, L, M, N
Molecule details ›
Chains: A, B, C, D, K, L, M, N
Length: 276 amino acids
Theoretical weight: 32.3 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8NE86 (Residues: 73-348; Coverage: 79%)
Gene names: C10orf42, CCDC109A, MCU
Sequence domains: Mitochondrial calcium uniporter
Essential MCU regulator, mitochondrial Chains: E, F, G, H, O, P, Q, R
Molecule details ›
Chains: E, F, G, H, O, P, Q, R
Length: 54 amino acids
Theoretical weight: 5.99 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9H4I9 (Residues: 48-101; Coverage: 51%)
Gene names: C22orf32, EMRE, SMDT1
Sequence domains: Putative mitochondrial precursor protein

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.27Å
Relevant EMDB volumes: EMD-9944
Expression system: Homo sapiens