› 6k9f

Electron Microscopy
3.7Å resolution

Structure of unknow protein 4

Released:
DOI: 10.2210/pdb6k9f/pdb
PDB entry 6k9f coloured by chain, front view.
PDB entry 6k9f coloured by chain, side view.
PDB entry 6k9f coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8.
Gong Q, Robinson K, Xu C, Huynh PT, Chong KHC, Tan EYJ, Zhang J, Boo ZZ, Teo DET, Lay K, Zhang Y, Lim JSY, Goh WI, Wright G, Zhong FL, Reversade B, Wu B
OpenAccess logo Nat Commun 12 188 (2021)
PMID: 33420028
Related structures: EMD-9948

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195127 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Caspase recruitment domain-containing protein 8, C-terminus Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 91 amino acids
Theoretical weight: 10.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y2G2 (Residues: 451-537; Coverage: 16%)
Gene names: CARD8, DACAR, KIAA0955, NDPP1
Sequence domains: Caspase recruitment domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.7Å
Relevant EMDB volumes: EMD-9948
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

17 review citations

Structural Mechanisms of NLRP3 Inflammasome Assembly and Activation.
Fu et al. (2023)
16 more

1 mention without citation

Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8.
Gong et al. (2021)