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Crystal structure of Plasmodium falciparum HPPK-DHPS wild type with pterin and p-hydroxybenzoate

Source organism: Plasmodium falciparum
Biochemical function: metal ion binding
Biological process: folic acid biosynthetic process
Cellular component: mitochondrial envelope

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EC 2.7.6.3: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase

Reaction catalysed:
ATP + 6-hydroxymethyl-7,8-dihydropterin = AMP + 6-hydroxymethyl-7,8-dihydropterin diphosphate
Systematic name:
ATP:6-hydroxymethyl-7,8-dihydropterin 6'-diphosphotransferase
Alternative Name(s):
  • 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
  • 6-hydroxymethyl-7,8-dihydropterin diphosphokinase
  • 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
  • 7,8-dihydro-6-hydroxymethylpterin diphosphokinase
  • 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase
  • 7,8-dihydroxymethylpterin-pyrophosphokinase
  • ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-diphosphotransferase
  • H(2)-Pteridine-CH(2)OH pyrophosphokinase
  • HPPK
  • Hydroxymethyldihydropteridine pyrophosphokinase

EC 2.5.1.15: Dihydropteroate synthase

Reaction catalysed:
6-hydroxymethyl-7,8-dihydropterin diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate
Systematic name:
6-hydroxymethyl-7,8-dihydropterin-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase
Alternative Name(s):
  • (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase
  • 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase
  • 7,8-dihydropteroate synthase
  • 7,8-dihydropteroate synthetase
  • 7,8-dihydropteroic acid synthetase
  • DHPS
  • Dihydropteroate diphosphorylase
  • Dihydropteroate pyrophosphorylase
  • Dihydropteroate synthetase
  • Dihydropteroic synthetase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00809
Domain description: Pterin binding enzyme
Occurring in:
  1. Pterin-binding domain-containing protein
The deposited structure of PDB entry 6kck contains 2 copies of Pfam domain PF00809 (Pterin binding enzyme) in Pterin-binding domain-containing protein. Showing 1 copy in chain B.

PF01288
Domain description: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)
Occurring in:
  1. Pterin-binding domain-containing protein
The deposited structure of PDB entry 6kck contains 2 copies of Pfam domain PF01288 (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)) in Pterin-binding domain-containing protein. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR000489
Domain description: Pterin-binding domain
Occurring in:
  1. Pterin-binding domain-containing protein
IPR011005
Domain description: Dihydropteroate synthase-like superfamily
Occurring in:
  1. Pterin-binding domain-containing protein
IPR035907
Domain description: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK superfamily
Occurring in:
  1. Pterin-binding domain-containing protein
IPR006390
Domain description: Dihydropteroate synthase domain
Occurring in:
  1. Pterin-binding domain-containing protein
IPR000550
Domain description: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK
Occurring in:
  1. Pterin-binding domain-containing protein
IPR045031
Domain description: Dihydropteroate synthase-like
Occurring in:
  1. Pterin-binding domain-containing protein

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