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AB loop engineered ferritin nanocages for drug loading under benign experimental conditions.

Wang W, Wang L, Li G, Zhao G, Zhao X, Wang H
Chem Commun (Camb) 55 12344-12347 (2019)
Cited: 5 times
EuropePMC logo PMID: 31556881

Abstract

Human ferritin has been explored as a potential drug nanocarrier, but extreme conditions (pH ≤ 2.0) are required for the encapsulation of drugs. Here, by engineering the AB loop of ferritin, we obtained a new ferritin variant with no new pores, which can disassemble at pH 3.0 or 4.0 and reassemble at pH 7.0. Consequently, under mild conditions, drugs can be encapsulated within this new ferritin nanocage.

Reviews citing this publication (3)

  1. Ferritin Nanocage: A Versatile Nanocarrier Utilized in the Field of Food, Nutrition, and Medicine. Zhang C, Zhang X, Zhao G. Nanomaterials (Basel) 10 E1894 (2020)
  2. Protein-Based Nanoparticles for the Imaging and Treatment of Solid Tumors: The Case of Ferritin Nanocages, a Narrative Review. Mainini F, Bonizzi A, Sevieri M, Sitia L, Truffi M, Corsi F, Mazzucchelli S. Pharmaceutics 13 2000 (2021)
  3. Ferritin-based nanomedicine for disease treatment. Zhu Y, Zhu Y, Cao T, Liu X, Liu X, Yan Y, Shi Y, Wang JC. Med Rev (Berl) 3 49-74 (2023)

Articles citing this publication (2)

  1. Anomalous SAXS at P12 beamline EMBL Hamburg: instrumentation and applications. Gruzinov AY, Schroer MA, Manalastas-Cantos K, Kikhney AG, Hajizadeh NR, Schulz F, Franke D, Svergun DI, Blanchet CE. J Synchrotron Radiat 28 812-823 (2021)
  2. Improving Blueberry Anthocyanins' Stability Using a Ferritin Nanocarrier. Huang W, Zhao X, Chai Z, Herrera-Balandrano DD, Li B, Yang Y, Lu S, Tu Z. Molecules 28 5844 (2023)


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