Function and Biology Details
Reaction catalysed:
S-adenosyl-L-methionine + a [histone H3]-L-lysine(4) = S-adenosyl-L-homocysteine + a [histone H3]-N(6)-methyl-L-lysine(4)
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero tetradecamer (preferred)
PDBe Complex ID:
PDB-CPX-120157 (preferred)
Entry contents:
8 distinct polypeptide molecules
2 distinct DNA molecules
2 distinct DNA molecules
Macromolecules (10 distinct):
Histone H3.2
Molecule details ›
Chains: A, E
Length: 135 amino acids
Theoretical weight: 15.3 KDa
Source organism: Xenopus laevis
Expression system: Escherichia coli
UniProt:
Length: 135 amino acids
Theoretical weight: 15.3 KDa
Source organism: Xenopus laevis
Expression system: Escherichia coli
UniProt:
- Canonical:
P84233 (Residues: 2-136; Coverage: 99%)
Histone H4
Molecule details ›
Chains: B, F
Length: 102 amino acids
Theoretical weight: 11.26 KDa
Source organism: Xenopus laevis
Expression system: Escherichia coli
UniProt:
Length: 102 amino acids
Theoretical weight: 11.26 KDa
Source organism: Xenopus laevis
Expression system: Escherichia coli
UniProt:
- Canonical: P62799 (Residues: 2-103; Coverage: 99%)
Histone H2A type 1
Histone H2B 1.1
Retinoblastoma-binding protein 5
MLL cleavage product C180
WD repeat-containing protein 5
Set1/Ash2 histone methyltransferase complex subunit ASH2
