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Crystal structure of API5-FGF2 complex

Source organism: Homo sapiens
Biochemical function: growth factor activity
Biological process: negative regulation of fibroblast apoptotic process
Cellular component: nuclear speck

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF00167
Domain description: Fibroblast growth factor
Occurring in:
  1. Fibroblast growth factor 2
The deposited structure of PDB entry 6l4o contains 1 copy of Pfam domain PF00167 (Fibroblast growth factor) in Fibroblast growth factor 2. Showing 1 copy in chain B.

PF05918
Domain description: Apoptosis inhibitory protein 5 (API5)
Occurring in:
  1. Apoptosis inhibitor 5
The deposited structure of PDB entry 6l4o contains 1 copy of Pfam domain PF05918 (Apoptosis inhibitory protein 5 (API5)) in Apoptosis inhibitor 5. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002209
Domain description: Fibroblast growth factor family
Occurring in:
  1. Fibroblast growth factor 2
IPR008383
Domain description: Apoptosis inhibitory 5
Occurring in:
  1. Apoptosis inhibitor 5
IPR008996
Domain description: Cytokine IL1/FGF
Occurring in:
  1. Fibroblast growth factor 2
IPR016024
Domain description: Armadillo-type fold
Occurring in:
  1. Apoptosis inhibitor 5
IPR011989
Domain description: Armadillo-like helical
Occurring in:
  1. Apoptosis inhibitor 5
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Apoptosis inhibitor 5

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