› 6lan

X-ray diffraction
1.41Å resolution

Structure of CCDC50 and LC3B complex

Released:
DOI: 10.2210/pdb6lan/pdb
PDB entry 6lan coloured by chain, front view.
PDB entry 6lan coloured by chain, side view.
PDB entry 6lan coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A novel selective autophagy receptor, CCDC50, delivers K63 polyubiquitination-activated RIG-I/MDA5 for degradation during viral infection.
Hou P, Yang K, Jia P, Liu L, Lin Y, Li Z, Li J, Chen S, Guo S, Pan J, Wu J, Peng H, Zeng W, Li C, Liu Y, Guo D
Cell Res 31 62-79 (2021)
PMID: 32612200

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184876 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Coiled-coil domain-containing protein 50; Microtubule-associated proteins 1A/1B light chain 3B Chain: A
Molecule details ›
Chain: A
Length: 135 amino acids
Theoretical weight: 15.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IVM0 (Residues: 170-178; Coverage: 3%)
  • Canonical: Q9GZQ8 (Residues: 2-125; Coverage: 99%)
Gene names: C3orf6, CCDC50, MAP1ALC3, MAP1LC3B
Sequence domains: Autophagy protein Atg8 ubiquitin like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL18U1
Spacegroup: C2
Unit cell:
a: 65.776Å b: 46.804Å c: 46.154Å
α: 90° β: 101.269° γ: 90°
R-values:
R R work R free
0.194 0.192 0.219
Expression system: Escherichia coli

Quick links

Citations

18 review citations

Pattern recognition receptors in health and diseases.
Li et al. (2021)
17 more

2 mentions without citation

A novel selective autophagy receptor, CCDC50, delivers K63 polyubiquitination-activated RIG-I/MDA5 for degradation during viral infection.
Hou et al. (2021)
1 more