Function and Biology

Cryo-EM structure of the Drosophila CTP synthase product-bound filament

Source organism: Drosophila melanogaster
Biochemical function: identical protein binding
Biological process: 'de novo' CTP biosynthetic process
Cellular component: cytoophidium

EC 6.3.4.2: CTP synthase (glutamine hydrolyzing)

Reaction catalysed:
(1a) L-glutamine + H(2)O = L-glutamate + NH(3)
Systematic name:
UTP:L-glutamine amido-ligase (ADP-forming)
Alternative Name(s):
  • CTP synthetase
  • CTPS (gene name)
  • Cytidine 5'-triphosphate synthetase
  • Cytidine triphosphate synthetase
  • PyrG (gene name)
  • UTP--ammonia ligase
  • Uridine triphosphate aminase

Sequence families

Pfam Protein families (Pfam)
PF00117
Domain description: Glutamine amidotransferase class-I
Occurring in:
  1. CTP synthase
The deposited structure of PDB entry 6lfg contains 8 copies of Pfam domain PF00117 (Glutamine amidotransferase class-I) in CTP synthase. Showing 1 copy in chain B [auth A].

PF06418
Domain description: CTP synthase N-terminus
Occurring in:
  1. CTP synthase
The deposited structure of PDB entry 6lfg contains 8 copies of Pfam domain PF06418 (CTP synthase N-terminus) in CTP synthase. Showing 1 copy in chain B [auth A].

InterPro InterPro annotations
IPR029062
Domain description: Class I glutamine amidotransferase-like
Occurring in:
  1. CTP synthase
IPR017456
Domain description: CTP synthase, N-terminal
Occurring in:
  1. CTP synthase
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. CTP synthase
IPR004468
Domain description: CTP synthase
Occurring in:
  1. CTP synthase
IPR017926
Domain description: Glutamine amidotransferase
Occurring in:
  1. CTP synthase
IPR033828
Domain description: CTP synthase GATase domain
Occurring in:
  1. CTP synthase