6lhq

Electron Microscopy
3.06Å resolution

The cryo-EM structure of coxsackievirus A16 mature virion in complex with Fab NA9D7

Released:

Function and Biology Details

Reactions catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
Selective cleavage of Tyr-|-Gly bond in picornavirus polyprotein.
NTP + H(2)O = NDP + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero 360-mer (preferred)
PDBe Complex ID:
PDB-CPX-212816 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (6 distinct):
Capsid protein VP1 Chain: A
Molecule details ›
Chain: A
Length: 297 amino acids
Theoretical weight: 33.11 KDa
Source organism: Coxsackievirus A16
Capsid protein VP2 Chain: B
Molecule details ›
Chain: B
Length: 254 amino acids
Theoretical weight: 27.56 KDa
Source organism: Coxsackievirus A16
Capsid protein VP3 Chain: C
Capsid protein VP4 Chain: D
light chain variable region of Fab NA9D7 Chain: L
heavy chain variable region of Fab NA9D7 Chain: H

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.06Å
Relevant EMDB volumes: EMD-0895