Function and Biology

Crystal structure of NDM-1 in complex with heterodimer of D-captopril derivative wss02127 stereoisomer

Source organism: Klebsiella pneumoniae
Biochemical function: metal ion binding
Biological process: response to antibiotic
Cellular component: periplasmic space

EC 3.5.2.6: Beta-lactamase

Reaction catalysed:
A beta-lactam + H(2)O = a substituted beta-amino acid
Systematic name:
Beta-lactam hydrolase
Alternative Name(s):
  • Ampicillinase
  • Beta-lactamase A, B, C
  • Beta-lactamase AME I
  • Beta-lactamase I-III
  • Cephalosporin-beta-lactamase
  • Cephalosporinase
  • Exopenicillinase
  • Neutrapen
  • Penicillin amido-beta-lactamhydrolase
  • Penicillin beta-lactamase
  • Penicillinase
  • Penicillinase I, II

Sequence family

Pfam Protein family (Pfam)
PF00753
Domain description: Metallo-beta-lactamase superfamily
Occurring in:
  1. Metallo-beta-lactamase type 2
The deposited structure of PDB entry 6lj2 contains 1 copy of Pfam domain PF00753 (Metallo-beta-lactamase superfamily) in Metallo-beta-lactamase type 2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001279
Domain description: Metallo-beta-lactamase
Occurring in:
  1. Metallo-beta-lactamase type 2
IPR036866
Domain description: Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
Occurring in:
  1. Metallo-beta-lactamase type 2