› 6lmh

X-ray diffraction
2.8Å resolution

Structure of an ASFV-derived histone-like protein pA104R

Released:
DOI: 10.2210/pdb6lmh/pdb
PDB entry 6lmh coloured by chain, front view.
PDB entry 6lmh coloured by chain, side view.
PDB entry 6lmh coloured by chain, top view.
Source organism: African swine fever virus
Primary publication:
The structural basis of African swine fever virus pA104R binding to DNA and its inhibition by stilbene derivatives.
Liu R, Sun Y, Chai Y, Li S, Li S, Wang L, Su J, Yu S, Yan J, Gao F, Zhang G, Qiu HJ, Gao GF, Qi J, Wang H
Proc Natl Acad Sci U S A 117 11000-11009 (2020)
PMID: 32358196

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159500 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Viral histone-like protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 110 amino acids
Theoretical weight: 12.46 KDa
Source organism: African swine fever virus
Expression system: Escherichia coli
UniProt:
  • Canonical: P68742 (Residues: 1-104; Coverage: 100%)
Gene names: A104R, BA71V-033
Sequence domains: Bacterial DNA-binding protein

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P3221
Unit cell:
a: 58.618Å b: 58.618Å c: 150.596Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.256 0.253 0.299
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Current State of Global African Swine Fever Vaccine Development under the Prevalence and Transmission of ASF in China.
Wu et al. (2020)
5 more

2 mentions without citation

Role of the DNA-Binding Protein pA104R in ASFV Genome Packaging and as a Novel Target for Vaccine and Drug Development.
Urbano et al. (2020)
1 more