Function and Biology

Cryo-EM structure of amyloid fibril formed by full-length human prion protein

Source organism: Homo sapiens
Biochemical function: cuprous ion binding
Biological process: neuron projection maintenance
Cellular component: postsynapse

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF00377
Domain description: Prion/Doppel alpha-helical domain
Occurring in:
  1. Major prion protein
The deposited structure of PDB entry 6lni contains 10 copies of Pfam domain PF00377 (Prion/Doppel alpha-helical domain) in Major prion protein. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR022416
Domain description: Prion/Doppel protein, beta-ribbon domain
Occurring in:
  1. Major prion protein
IPR036924
Domain description: Prion/Doppel beta-ribbon domain superfamily
Occurring in:
  1. Major prion protein
IPR000817
Domain description: Prion protein
Occurring in:
  1. Major prion protein