› 6lor

X-ray diffraction
1.35Å resolution

crystal structure of alpha-momorcharin in complex with ADP

Released:
DOI: 10.2210/pdb6lor/pdb
PDB entry 6lor coloured by chain, front view.
PDB entry 6lor coloured by chain, side view.
PDB entry 6lor coloured by chain, top view.
Source organism: Momordica charantia
Primary publication:
Atomic-resolution structures of type I ribosome inactivating protein alpha-momorcharin with different substrate analogs.
Fan X, Wang Y, Guo F, Zhang Y, Jin T
Int J Biol Macromol 164 265-276 (2020)
PMID: 32653369

Function and Biology Details

Reaction catalysed: 
Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147607 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribosome-inactivating protein momordin I Chain: A
Molecule details ›
Chain: A
Length: 286 amino acids
Theoretical weight: 31.56 KDa
Source organism: Momordica charantia
UniProt:
  • Canonical: P16094 (Residues: 1-286; Coverage: 100%)
Sequence domains: Ribosome inactivating protein

Ligands and Environments

2 bound ligands:
Ligand ADP 1 x ADP
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: R3
Unit cell:
a: 130.361Å b: 130.361Å c: 39.333Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.219 0.218 0.251

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