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Crystal Structure of human glutaminase with macrocyclic inhibitor

X-ray diffraction
3.2Å resolution
PDB entry 6lox coloured by chain, front view.
PDB entry 6lox coloured by chain, side view.
PDB entry 6lox coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Glutaminase kidney isoform, mitochondrial 65 kDa chain
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Multimeric state: homo tetramer
Accessible surface area: 58058.3 Å2
Buried surface area: 9478.37 Å2
Dissociation area: 1,424.12 Å2
Dissociation energy (ΔGdiss): 6.41 kcal/mol
Dissociation entropy (TΔSdiss): 15.34 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-131797

Macromolecules

Glutaminase kidney isoform, mitochondrial 65 kDa chain
Chains: A, B, C, D
Length: 534 amino acids
Theoretical weight: 58.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O94925 (Residues: 71-600; Coverage: 79%)
  • Best match: O94925-3 (Residues: 71-598)
Gene names: GLS, GLS1, KIAA0838
Pfam:
InterPro:
Glutaminase kidney isoform, mitochondrial 65 kDa chain in PDB entry 6lox, assembly 1, front view.
Glutaminase kidney isoform, mitochondrial 65 kDa chain in PDB entry 6lox, assembly 1, side view.
Glutaminase kidney isoform, mitochondrial 65 kDa chain in PDB entry 6lox, assembly 1, top view.
PDBe-KB: UniProt Coverage View: O94925  
153450100150200250300350400450500
 
200400
UniProt
O94925
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