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Molecular basis for inhibition of human gamma-secretase by small molecule

Source organism: Homo sapiens
Biochemical function: protein binding
Biological process: protein processing
Cellular component: membrane

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GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF10251
Domain description: Presenilin enhancer-2 subunit of gamma secretase
Occurring in:
  1. Gamma-secretase subunit PEN-2
The deposited structure of PDB entry 6lr4 contains 1 copy of Pfam domain PF10251 (Presenilin enhancer-2 subunit of gamma secretase) in Gamma-secretase subunit PEN-2. Showing 1 copy in chain D.

PF06105
Domain description: Aph-1 protein
Occurring in:
  1. Gamma-secretase subunit APH-1A
The deposited structure of PDB entry 6lr4 contains 1 copy of Pfam domain PF06105 (Aph-1 protein) in Gamma-secretase subunit APH-1A. Showing 1 copy in chain C.

PF01080
Domain description: Presenilin
Occurring in:
  1. Presenilin-1
The deposited structure of PDB entry 6lr4 contains 1 copy of Pfam domain PF01080 (Presenilin) in Presenilin-1. Showing 1 copy in chain B.

PF05450
Domain description: Nicastrin
Occurring in:
  1. Nicastrin
The deposited structure of PDB entry 6lr4 contains 1 copy of Pfam domain PF05450 (Nicastrin) in Nicastrin. Showing 1 copy in chain A.

PF18266
Domain description: Nicastrin small lobe
Occurring in:
  1. Nicastrin
The deposited structure of PDB entry 6lr4 contains 1 copy of Pfam domain PF18266 (Nicastrin small lobe) in Nicastrin. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001108
Domain description: Peptidase A22A, presenilin
Occurring in:
  1. Presenilin-1
IPR002031
Domain description: Peptidase A22A, presenilin 1
Occurring in:
  1. Presenilin-1
IPR019379
Domain description: Gamma-secretase aspartyl protease complex, presenilin enhancer-2 subunit
Occurring in:
  1. Gamma-secretase subunit PEN-2
IPR009294
Domain description: Gamma-secretase subunit Aph-1
Occurring in:
  1. Gamma-secretase subunit APH-1A
IPR042524
Domain description: Presenilin, C-terminal
Occurring in:
  1. Presenilin-1
IPR006639
Domain description: Presenilin/signal peptide peptidase
Occurring in:
  1. Presenilin-1
IPR041084
Domain description: Nicastrin, small lobe
Occurring in:
  1. Nicastrin
IPR008710
Domain description: Nicastrin
Occurring in:
  1. Nicastrin

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