6lth

Electron Microscopy
3Å resolution

Structure of human BAF Base module

Released:
Source organism: Homo sapiens
Primary publication:
Structure of nucleosome-bound human BAF complex.
Science 367 875-881 (2020)
PMID: 32001526
Related structures: EMD-0968

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
PDBe Complex ID:
PDB-CPX-126984 (preferred)
Entry contents:
7 distinct polypeptide molecules
Macromolecules (7 distinct):
Transcription activator BRG1 Chain: I
Molecule details ›
Chain: I
Length: 1647 amino acids
Theoretical weight: 184.92 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P51532 (Residues: 1-1647; Coverage: 100%)
Gene names: BAF190A, BRG1, SMARCA4, SNF2B, SNF2L4
Sequence domains:
AT-rich interactive domain-containing protein 1A Chain: L
Molecule details ›
Chain: L
Length: 2285 amino acids
Theoretical weight: 242.25 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O14497 (Residues: 1-2285; Coverage: 100%)
Gene names: ARID1A, BAF250, BAF250A, C1orf4, OSA1, SMARCF1
Sequence domains:
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 Chain: M
SWI/SNF complex subunit SMARCC2 Chains: N, O
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 Chain: P
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 Chain: Q
Zinc finger protein ubi-d4 Chain: R

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution:
Relevant EMDB volumes: EMD-0968
Expression system: Homo sapiens