› 6m23

Electron Microscopy
3.2Å resolution

Overall structure of KCC2

Released:
DOI: 10.2210/pdb6m23/pdb
PDB entry 6m23 coloured by chain, front view.
PDB entry 6m23 coloured by chain, side view.
PDB entry 6m23 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structures of the full-length human KCC2 and KCC3 cation-chloride cotransporters.
Chi X, Li X, Chen Y, Zhang Y, Su Q, Zhou Q
OpenAccess logo Cell Res 31 482-484 (2021)
PMID: 33199848
Related structures: EMD-30061

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190563 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Solute carrier family 12 member 5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 1129 amino acids
Theoretical weight: 125.3 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9H2X9 (Residues: 26-1139; Coverage: 98%)
  • Best match: Q9H2X9-2 (Residues: 1-1116)
Gene names: KCC2, KIAA1176, SLC12A5
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
3 bound ligands:
Ligand K 2 x K
Ligand CL 2 x CL
Ligand NAG 2 x NAG
1 modified residue:
Ligand TPO 4 x TPO

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-30061
Expression system: Homo sapiens

Quick links

Citations

7 review citations

High-Resolution Views and Transport Mechanisms of the NKCC1 and KCC Transporters.
Chew et al. (2021)
6 more

8 mentions without citation

New and Emerging Research on Solute Carrier and ATP Binding Cassette Transporters in Drug Discovery and Development: Outlook From the International Transporter Consortium.
Giacomini et al. (2022)
7 more