› 6m4t

X-ray diffraction
1.55Å resolution

U shaped head to head four-way junction in d(TTCTGCTGCTGAA) sequence

Released:
DOI: 10.2210/pdb6m4t/pdb
PDB entry 6m4t coloured by chain, front view.
PDB entry 6m4t coloured by chain, side view.
PDB entry 6m4t coloured by chain, top view.
Source organism: synthetic construct
Primary publication:
Structural Basis for Targeting T:T Mismatch with Triaminotriazine-Acridine Conjugate Induces a U-Shaped Head-to-Head Four-Way Junction in CTG Repeat DNA.
Chien CM, Wu PC, Satange R, Chang CC, Lai ZL, Hagler LD, Zimmerman SC, Hou MH
J Am Chem Soc 142 11165-11172 (2020)
PMID: 32478511

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-120265 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(P*(UD)P*TP*CP*TP*GP*CP*TP*GP*CP*TP*GP*AP*A)-3') Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 13 nucleotides
Theoretical weight: 4.02 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand CO 4 x CO
Ligand F1R 4 x F1R
1 modified residue:
Ligand BRU 4 x BRU

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE TPS 05A
Spacegroup: P21
Unit cell:
a: 57.204Å b: 62.631Å c: 29.743Å
α: 90° β: 121.29° γ: 90°
R-values:
R R work R free
0.168 0.165 0.19
Expression system: Not provided

Quick links

Citations

2 review citations

DNA Holliday Junction: History, Regulation and Bioactivity.
Song et al. (2022)
1 more

1 mention without citation

Interactions of small molecules with DNA junctions.
McQuaid et al. (2022)