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Crystal structure of human O-GlcNAc transferase bound to a peptide from HCF-1 pro-repeat 2 (11-26) and inhibitor 4a

Source organism: Homo sapiens
Biochemical function: glycosyltransferase activity
Biological process: protein O-linked glycosylation
Cellular component: not assigned

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EC 2.4.1.255: Protein O-GlcNAc transferase

Reaction catalysed:
UDP-N-acetyl-alpha-D-glucosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine
Systematic name:
UDP-N-acetyl-D-glucosamine:protein-O-beta-N-acetyl-D-glucosaminyl transferase
Alternative Name(s):
  • O-GlcNAc transferase
  • O-linked N-acetylglucosaminyltransferase
  • OGTase
  • Protein O-linked beta-N-acetylglucosamine transferase
  • Uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyltransferase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF13414
Domain description: TPR repeat
Occurring in:
  1. UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
The deposited structure of PDB entry 6ma1 contains 3 copies of Pfam domain PF13414 (TPR repeat) in UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit. Showing 3 copies in chain A.

PF13844
Domain description: Glycosyl transferase family 41
Occurring in:
  1. UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
The deposited structure of PDB entry 6ma1 contains 1 copy of Pfam domain PF13844 (Glycosyl transferase family 41) in UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit. Showing 1 copy in chain A.

PF13424
Domain description: Tetratricopeptide repeat
Occurring in:
  1. UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
The deposited structure of PDB entry 6ma1 contains 1 copy of Pfam domain PF13424 (Tetratricopeptide repeat) in UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR019734
Domain description: Tetratricopeptide repeat
Occurring in:
  1. UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
IPR011990
Domain description: Tetratricopeptide-like helical domain superfamily
Occurring in:
  1. UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
IPR029489
Domain description: O-GlcNAc transferase, C-terminal
Occurring in:
  1. UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
IPR037919
Domain description: UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110kDa subunit
Occurring in:
  1. UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

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