› 6mc0

X-ray diffraction
2Å resolution

Crystal Structure of Ribose-5-phosphate Isomerase from Legionella pneumophila with Bound Substrate Ribose-5-Phosphate and Product Ribulose-5-Phosphate

Released:
DOI: 10.2210/pdb6mc0/pdb
PDB entry 6mc0 coloured by chain, front view.
PDB entry 6mc0 coloured by chain, side view.
PDB entry 6mc0 coloured by chain, top view.
Source organism: Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Entry author: Seattle Structural Genomics Center for Infectious Disease (SSGCID)

Function and Biology Details

Reaction catalysed: 
D-ribose 5-phosphate = D-ribulose 5-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178741 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribose-5-phosphate isomerase A Chains: A, B
Molecule details ›
Chains: A, B
Length: 224 amino acids
Theoretical weight: 24.08 KDa
Source organism: Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q5ZZB7 (Residues: 1-216; Coverage: 100%)
Gene names: lpg0094, rpiA
Sequence domains: Ribose 5-phosphate isomerase A (phosphoriboisomerase A)
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand R5P 1 x R5P
Ligand NA 2 x NA
Ligand 5RP 1 x 5RP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ SUPERBRIGHT
Spacegroup: C2
Unit cell:
a: 103.29Å b: 67.56Å c: 73.32Å
α: 90° β: 118.82° γ: 90°
R-values:
R R work R free
0.158 0.154 0.203
Expression system: Escherichia coli BL21(DE3)

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