› 6me2

X-ray diffraction
2.8Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155693 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Melatonin receptor type 1A; Starch synthase catalytic domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 503 amino acids
Theoretical weight: 56.65 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P48039 (Residues: 12-218, 228-325; Coverage: 87%)
  • Canonical: Q9V2J8 (Residues: 218-413; Coverage: 45%)
Gene names: MTNR1A, PAB2292
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand JEV 1 x JEV
Ligand OLA 2 x OLA
Ligand PEG 1 x PEG
1 modified residue:
Ligand YCM 2 x YCM

Experiments and Validation Details

Entry percentile scores
X-ray source: SLAC LCLS BEAMLINE CXI
Spacegroup: P4212
Unit cell:
a: 122.3Å b: 122.3Å c: 122.8Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.204 0.228
Expression system: Spodoptera frugiperda

Quick links

Citations

16 review citations

Circadian rhythm as a therapeutic target.
Ruan et al. (2021)
15 more

12 mentions without citation

G protein-coupled receptors: structure- and function-based drug discovery.
Yang et al. (2021)
11 more