› 6meo

Electron Microscopy
3.9Å resolution

Structural basis of coreceptor recognition by HIV-1 envelope spike

Released:
DOI: 10.2210/pdb6meo/pdb
PDB entry 6meo coloured by chain, front view.
PDB entry 6meo coloured by chain, side view.
PDB entry 6meo coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis of coreceptor recognition by HIV-1 envelope spike.
Shaik MM, Peng H, Lu J, Rits-Volloch S, Xu C, Liao M, Chen B
OpenAccess logo Nature 565 318-323 (2019)
PMID: 30542158
Related structures: EMD-9108

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-525224 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (6 distinct):
Envelope glycoprotein gp160 Chain: G
Molecule details ›
Chain: G
Length: 461 amino acids
Theoretical weight: 51.47 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: Q70145 (Residues: 29-489; Coverage: 54%)
Gene name: env
Sequence domains: Envelope glycoprotein GP120
T-cell surface glycoprotein CD4 Chain: A
Molecule details ›
Chain: A
Length: 176 amino acids
Theoretical weight: 19.54 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01730 (Residues: 26-201; Coverage: 41%)
Gene name: CD4
Sequence domains:
Structure domains: Immunoglobulins
C-C chemokine receptor type 5 Chain: B
Molecule details ›
Chain: B
Length: 313 amino acids
Theoretical weight: 36.34 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P51681 (Residues: 1-313; Coverage: 89%)
Gene names: CCR5, CMKBR5
Sequence domains: 7 transmembrane receptor (rhodopsin family)

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
3 bound ligands:
Ligand NAG 7 x NAG
Ligand BMA 1 x BMA
Ligand A2G 1 x A2G
1 modified residue:
Ligand TYS 2 x TYS

Experiments and Validation Details

Entry percentile scores
Resolution: 3.9Å
Relevant EMDB volumes: EMD-9108
Expression system: Homo sapiens

Quick links

Citations

26 review citations

Mechanisms of SARS-CoV-2 entry into cells.
Jackson et al. (2022)
25 more

28 mentions without citation

G protein-coupled receptors: structure- and function-based drug discovery.
Yang et al. (2021)
27 more