› 6mer

X-ray diffraction
3Å resolution

PcdhgB3 EC1-4 in 50 mM HEPES

Released:
DOI: 10.2210/pdb6mer/pdb
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PDB entry 6mer coloured by chain, front view.
PDB entry 6mer coloured by chain, side view.
PDB entry 6mer coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Interaction specificity of clustered protocadherins inferred from sequence covariation and structural analysis.
Nicoludis JM, Green AG, Walujkar S, May EJ, Sotomayor M, Marks DS, Gaudet R
Proc Natl Acad Sci U S A 116 17825-17830 (2019)
PMID: 31431536

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195270 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protocadherin gamma-B3 Chain: A
Molecule details ›
Chain: A
Length: 416 amino acids
Theoretical weight: 45.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9Y5G1 (Residues: 31-444; Coverage: 46%)
Gene name: PCDHGB3
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand CA 9 x CA
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: C2221
Unit cell:
a: 128.39Å b: 161.77Å c: 52.16Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.229 0.224 0.272
Expression system: Escherichia coli BL21

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Citations

6 review citations

Protocadherins at the Crossroad of Signaling Pathways.
Pancho et al. (2020)
5 more

65 mentions without citation

Silk-based delivery systems of bioactive molecules.
Numata et al. (2010)
64 more

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