› 6mj3

X-ray diffraction
3.8Å resolution

CRYSTAL STRUCTURE OF RHESUS MACAQUE (MACACA MULATTA) IGG1 Fc Fragment-Fc-GAMMA RECEPTOR III complex

Released:
DOI: 10.2210/pdb6mj3/pdb
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PDB entry 6mj3 coloured by chain, front view.
PDB entry 6mj3 coloured by chain, side view.
PDB entry 6mj3 coloured by chain, top view.
Source organism: Macaca mulatta
Primary publication:
Decoding human-macaque interspecies differences in Fc-effector functions: The structural basis for CD16-dependent effector function in Rhesus macaques.
Tolbert WD, Gohain N, Kremer PG, Hederman AP, Nguyen DN, Van V, Sherburn R, Lewis GK, Finzi A, Pollara J, Ackerman ME, Barb AW, Pazgier M
OpenAccess logo Front Immunol 13 960411 (2022)
PMID: 36131913

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-107224 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Ig-like domain-containing protein Chains: A, B, D, E
Molecule details ›
Chains: A, B, D, E
Length: 224 amino acids
Theoretical weight: 25.14 KDa
Source organism: Macaca mulatta
Expression system: Homo sapiens
UniProt:
  • Canonical: F6RL33 (Residues: 143-365; Coverage: 61%)
Sequence domains: Immunoglobulin C1-set domain
Low affinity immunoglobulin gamma Fc region receptor III-A Chains: C, F
Molecule details ›
Chains: C, F
Length: 192 amino acids
Theoretical weight: 21.99 KDa
Source organism: Macaca mulatta
Expression system: Homo sapiens
UniProt:
  • Canonical: A3RFZ7 (Residues: 18-209; Coverage: 81%)
Gene names: FCGR3, FCGR3A
Sequence domains: Immunoglobulin domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN, FUC
Carbohydrate polymer
1 bound ligand:
Ligand NAG 3 x NAG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: C2
Unit cell:
a: 213.108Å b: 71.27Å c: 135.521Å
α: 90° β: 119.72° γ: 90°
R-values:
R R work R free
0.278 0.276 0.324
Expression system: Homo sapiens

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Citations

8 citation in other articles

Macrophage N-glycan processing inhibits antibody-dependent cellular phagocytosis.
Díaz de León et al. (2023)
7 more

1 mention without citation

Decoding human-macaque interspecies differences in Fc-effector functions: The structural basis for CD16-dependent effector function in Rhesus macaques.
Tolbert et al. (2022)

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