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CENP-A nucleosome bound by two copies of CENP-C(CD) and two copies CENP-N(NT)

Source organism: Homo sapiens
Biochemical function: protein heterodimerization activity
Biological process: CENP-A containing chromatin assembly
Cellular component: nucleosome

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF00125
Domain description: Core histone H2A/H2B/H3/H4
Occurring in:
  1. Histone H3-like centromeric protein A
  2. Histone H2A type 1-C
  3. Histone H2B type 2-F
The deposited structure of PDB entry 6mup contains 2 copies of Pfam domain PF00125 (Core histone H2A/H2B/H3/H4) in Histone H3-like centromeric protein A. Showing 1 copy in chain A.
The deposited structure of PDB entry 6mup contains 2 copies of Pfam domain PF00125 (Core histone H2A/H2B/H3/H4) in Histone H2A type 1-C. Showing 1 copy in chain G.
The deposited structure of PDB entry 6mup contains 2 copies of Pfam domain PF00125 (Core histone H2A/H2B/H3/H4) in Histone H2B type 2-F. Showing 1 copy in chain D.

PF05238
Domain description: Kinetochore protein CHL4 like
Occurring in:
  1. Centromere protein N
The deposited structure of PDB entry 6mup contains 2 copies of Pfam domain PF05238 (Kinetochore protein CHL4 like) in Centromere protein N. Showing 1 copy in chain M.

PF16211
Domain description: C-terminus of histone H2A
Occurring in:
  1. Histone H2A type 1-C
The deposited structure of PDB entry 6mup contains 2 copies of Pfam domain PF16211 (C-terminus of histone H2A) in Histone H2A type 1-C. Showing 1 copy in chain G.

PF15511
Domain description: Centromere kinetochore component CENP-T histone fold
Occurring in:
  1. Histone H4
The deposited structure of PDB entry 6mup contains 2 copies of Pfam domain PF15511 (Centromere kinetochore component CENP-T histone fold) in Histone H4. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR000558
Domain description: Histone H2B
Occurring in:
  1. Histone H2B type 2-F
IPR001951
Domain description: Histone H4
Occurring in:
  1. Histone H4
IPR009072
Domain description: Histone-fold
Occurring in:
  1. Histone H3-like centromeric protein A
  2. Histone H4
  3. Histone H2A type 1-C
  4. Histone H2B type 2-F
IPR002119
Domain description: Histone H2A
Occurring in:
  1. Histone H2A type 1-C
IPR000164
Domain description: Histone H3/CENP-A
Occurring in:
  1. Histone H3-like centromeric protein A
IPR007125
Domain description: Histone H2A/H2B/H3
Occurring in:
  1. Histone H3-like centromeric protein A
  2. Histone H2A type 1-C
  3. Histone H2B type 2-F
IPR007902
Domain description: Centromere protein Chl4/mis15/CENP-N
Occurring in:
  1. Centromere protein N
IPR028931
Domain description: CENP-C, middle DNMT3B-binding domain
Occurring in:
  1. Centromere protein C
IPR032454
Domain description: Histone H2A, C-terminal domain
Occurring in:
  1. Histone H2A type 1-C
IPR032458
Domain description: Histone H2A conserved site
Occurring in:
  1. Histone H2A type 1-C
IPR035425
Domain description: CENP-T/Histone H4, histone fold
Occurring in:
  1. Histone H4
IPR004823
Domain description: TATA box binding protein associated factor (TAF), histone-like fold domain
Occurring in:
  1. Histone H4
IPR019809
Domain description: Histone H4, conserved site
Occurring in:
  1. Histone H4

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