Function and Biology

The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators

Source organism: Plasmodium falciparum 3D7
Biochemical function: hydrolase activity
Biological process: proteolysis involved in protein catabolic process
Cellular component: cytoplasm

EC 3.4.25.1: Proteasome endopeptidase complex

Reaction catalysed:
Cleavage of peptide bonds with very broad specificity.
Alternative Name(s):
  • 26S protease
  • Alkaline protease
  • Ingensin
  • Large multicatalytic protease
  • Lens neutral proteinase
  • MCP
  • Macropain
  • Multicatalytic endopeptidase complex
  • Multicatalytic proteinase
  • Multicatalytic proteinase (complex)
  • Prosome
  • Proteasome
  • Proteasome organelle
  • Tricorn protease
  • Tricorn proteinase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
InterPro InterPro annotations
IPR000243
Domain description: Peptidase T1A, proteasome beta-subunit
Occurring in:
  1. Proteasome subunit beta
  2. Proteasome subunit beta
IPR003186
Domain description: Proteasome activator PA28, C-terminal domain
Occurring in:
  1. Proteasome activator PA28 C-terminal domain-containing protein
IPR036997
Domain description: Proteasome activator PA28, C-terminal domain superfamily
Occurring in:
  1. Proteasome activator PA28 C-terminal domain-containing protein
IPR036252
Domain description: Proteasome activator superfamily
Occurring in:
  1. Proteasome activator PA28 C-terminal domain-containing protein
IPR009077
Domain description: Proteasome activator PA28
Occurring in:
  1. Proteasome activator PA28 C-terminal domain-containing protein
IPR016050
IPR016295
Domain description: Proteasome subunit beta 4
Occurring in:
  1. Proteasome subunit beta
IPR035206
Domain description: Proteasome subunit beta 2
Occurring in:
  1. Proteasome subunit beta
IPR033811
Domain description: Proteasome beta 3 subunit
Occurring in:
  1. Proteasome subunit beta
IPR035144
Domain description: Proteasome subunit alpha 1
Occurring in:
  1. Proteasome alpha-type subunits domain-containing protein
IPR033812
Domain description: Proteasome subunit alpha5
Occurring in:
  1. Proteasome subunit alpha type
IPR034642
Domain description: Proteasome subunit alpha6
Occurring in:
  1. Proteasome alpha-type subunits domain-containing protein