› 6mvx

X-ray diffraction
3.46Å resolution

NavAb Voltage-gated Sodium Channel, I217C, in Complex with Class 1C Anti-arrhythmic Flecainide

Released:
DOI: 10.2210/pdb6mvx/pdb
PDB entry 6mvx coloured by chain, front view.
PDB entry 6mvx coloured by chain, side view.
PDB entry 6mvx coloured by chain, top view.
Source organism: Aliarcobacter butzleri RM4018
Primary publication:
Fenestrations control resting-state block of a voltage-gated sodium channel.
Gamal El-Din TM, Lenaeus MJ, Zheng N, Catterall WA
Proc Natl Acad Sci U S A 115 13111-13116 (2018)
PMID: 30518562

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-108631 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ion transport domain-containing protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 285 amino acids
Theoretical weight: 33.11 KDa
Source organism: Aliarcobacter butzleri RM4018
Expression system: Trichoplusia ni
UniProt:
  • Canonical: A8EVM5 (Residues: 1-267; Coverage: 100%)
Gene name: Abu_1752
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand PO4 10 x PO4
Ligand K4D 1 x K4D
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: C2221
Unit cell:
a: 177.525Å b: 177.687Å c: 192.923Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.236 0.23 0.263
Expression system: Trichoplusia ni

Quick links

Citations

15 review citations

Ligand binding at the protein-lipid interface: strategic considerations for drug design.
Payandeh et al. (2021)
14 more

4 mentions without citation

Sodium Channels and Local Anesthetics-Old Friends With New Perspectives.
Körner et al. (2022)
3 more