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EM structure of Bacillus subtilis ribonucleotide reductase inhibited filament composed of NrdE alpha subunit and NrdF beta subunit with dATP

Source organism: Bacillus subtilis
Biochemical function: oxidoreductase activity
Biological process: deoxyribonucleotide biosynthetic process
Cellular component: ribonucleoside-diphosphate reductase complex

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EC 1.17.4.1: Ribonucleoside-diphosphate reductase

Reaction catalysed:
2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H(2)O = ribonucleoside diphosphate + thioredoxin
Systematic name:
2'-deoxyribonucleoside-diphosphate:thioredoxin-disulfide 2'-oxidoreductase
Alternative Name(s):
  • 2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2'-oxidoreductase
  • ADP reductase
  • CDP reductase
  • NrdB (gene name)
  • NrdF (gene name)
  • NrdJ (gene name)
  • Nucleoside diphosphate reductase
  • RR
  • Ribonucleoside 5'-diphosphate reductase
  • Ribonucleoside diphosphate reductase
  • Ribonucleotide diphosphate reductase
  • Ribonucleotide reductase
  • UDP reductase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF02867
Domain description: Ribonucleotide reductase, barrel domain
Occurring in:
  1. Ribonucleoside-diphosphate reductase subunit alpha
The deposited structure of PDB entry 6mw3 contains 2 copies of Pfam domain PF02867 (Ribonucleotide reductase, barrel domain) in Ribonucleoside-diphosphate reductase subunit alpha. Showing 1 copy in chain A [auth C].

PF00317
Domain description: Ribonucleotide reductase, all-alpha domain
Occurring in:
  1. Ribonucleoside-diphosphate reductase subunit alpha
The deposited structure of PDB entry 6mw3 contains 2 copies of Pfam domain PF00317 (Ribonucleotide reductase, all-alpha domain) in Ribonucleoside-diphosphate reductase subunit alpha. Showing 1 copy in chain A [auth C].

PF08343
Domain description: Ribonucleotide reductase N-terminal
Occurring in:
  1. Ribonucleoside-diphosphate reductase subunit alpha
The deposited structure of PDB entry 6mw3 contains 2 copies of Pfam domain PF08343 (Ribonucleotide reductase N-terminal) in Ribonucleoside-diphosphate reductase subunit alpha. Showing 1 copy in chain A [auth C].

InterPro InterPro annotations
IPR000788
Domain description: Ribonucleotide reductase large subunit, C-terminal
Occurring in:
  1. Ribonucleoside-diphosphate reductase subunit alpha
IPR013346
Domain description: Ribonucleotide reductase, class I, alpha subunit, C-terminal
Occurring in:
  1. Ribonucleoside-diphosphate reductase subunit alpha
IPR013509
Domain description: Ribonucleotide reductase large subunit, N-terminal
Occurring in:
  1. Ribonucleoside-diphosphate reductase subunit alpha
IPR013554
Domain description: Ribonucleotide reductase N-terminal
Occurring in:
  1. Ribonucleoside-diphosphate reductase subunit alpha
IPR026459
Domain description: Ribonucleotide reductase, class 1b, subunit NrdE
Occurring in:
  1. Ribonucleoside-diphosphate reductase subunit alpha
IPR008926
Domain description: Ribonucleotide reductase R1 subunit, N-terminal
Occurring in:
  1. Ribonucleoside-diphosphate reductase subunit alpha
IPR039718
Domain description: Ribonucleoside-diphosphate reductase large subunit
Occurring in:
  1. Ribonucleoside-diphosphate reductase subunit alpha

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