› 6mxx

X-ray diffraction
2.3Å resolution

Structure of 53BP1 tandem Tudor domains in complex with small molecule UNC2991

Released:
DOI: 10.2210/pdb6mxx/pdb
PDB entry 6mxx coloured by chain, front view.
PDB entry 6mxx coloured by chain, side view.
PDB entry 6mxx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering.
Cui G, Botuyan MV, Drané P, Hu Q, Bragantini B, Thompson JR, Schuller DJ, Detappe A, Perfetti MT, James LI, Frye SV, Chowdhury D, Mer G
OpenAccess logo Nat Commun 14 6091 (2023)
PMID: 37773238

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171427 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TP53-binding protein 1 Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 123 amino acids
Theoretical weight: 13.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q12888 (Residues: 1484-1603; Coverage: 6%)
Gene name: TP53BP1
Sequence domains: Tumour suppressor p53-binding protein-1 Tudor

Ligands and Environments

3 bound ligands:
Ligand PO4 21 x PO4
Ligand K6P 5 x K6P
Ligand FMT 4 x FMT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P212121
Unit cell:
a: 68.94Å b: 159.43Å c: 181.19Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.206 0.232
Expression system: Escherichia coli

Quick links

Citations

2 mentions without citation

An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering.
Cui et al. (2023)
1 more