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Dihedral oligomeric complex of GyrA N-terminal fragment, solved by cryoEM in D2 symmetry

Source organism: Streptococcus pneumoniae G54
Biochemical function: ATP binding
Biological process: DNA topological change
Cellular component: not assigned

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EC 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing)

Reaction catalysed:
ATP-dependent breakage, passage and rejoining of double-stranded DNA
Systematic name:
DNA topoisomerase (ATP-hydrolyzing)
Alternative Name(s):
  • DNA gyrase
  • DNA topoisomerase II
  • Type II DNA topoisomerase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00521
Domain description: DNA gyrase/topoisomerase IV, subunit A
Occurring in:
  1. DNA gyrase subunit A
The deposited structure of PDB entry 6n1q contains 8 copies of Pfam domain PF00521 (DNA gyrase/topoisomerase IV, subunit A) in DNA gyrase subunit A. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR002205
Domain description: DNA topoisomerase, type IIA, domain A
Occurring in:
  1. DNA gyrase subunit A
IPR013757
Domain description: DNA topoisomerase, type IIA, alpha-helical domain superfamily
Occurring in:
  1. DNA gyrase subunit A
IPR013758
Domain description: DNA topoisomerase, type IIA, domain A, alpha-beta
Occurring in:
  1. DNA gyrase subunit A
IPR013760
Domain description: DNA topoisomerase, type IIA-like domain superfamily
Occurring in:
  1. DNA gyrase subunit A

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