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Meso-Diaminopimelate Decarboxylase from Arabidopsis thaliana (Isoform 1)

Source organism: Arabidopsis thaliana
Biochemical function: diaminopimelate decarboxylase activity
Biological process: lysine biosynthetic process via diaminopimelate
Cellular component: not assigned

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EC 4.1.1.20: Diaminopimelate decarboxylase

Reaction catalysed:
Meso-2,6-diaminoheptanedioate = L-lysine + CO(2)
Systematic name:
Meso-2,6-diaminoheptanedioate carboxy-lyase (L-lysine-forming)
Alternative Name(s):
  • DAP decarboxylase
  • DAP-decarboxylase
  • Diaminopimelic acid decarboxylase
  • Meso-2,6-diaminoheptanedioate carboxy-lyase
  • Meso-diaminopimelate decarboxylase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF02784
Domain description: Pyridoxal-dependent decarboxylase, pyridoxal binding domain
Occurring in:
  1. Diaminopimelate decarboxylase 1, chloroplastic
The deposited structure of PDB entry 6n2a contains 2 copies of Pfam domain PF02784 (Pyridoxal-dependent decarboxylase, pyridoxal binding domain) in Diaminopimelate decarboxylase 1, chloroplastic. Showing 1 copy in chain A.

PF00278
Domain description: Pyridoxal-dependent decarboxylase, C-terminal sheet domain
Occurring in:
  1. Diaminopimelate decarboxylase 1, chloroplastic
The deposited structure of PDB entry 6n2a contains 2 copies of Pfam domain PF00278 (Pyridoxal-dependent decarboxylase, C-terminal sheet domain) in Diaminopimelate decarboxylase 1, chloroplastic. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002986
Domain description: Diaminopimelate decarboxylase, LysA
Occurring in:
  1. Diaminopimelate decarboxylase 1, chloroplastic
IPR000183
Domain description: Ornithine/DAP/Arg decarboxylase
Occurring in:
  1. Diaminopimelate decarboxylase 1, chloroplastic
IPR029066
Domain description: PLP-binding barrel
Occurring in:
  1. Diaminopimelate decarboxylase 1, chloroplastic
IPR009006
Domain description: Alanine racemase/group IV decarboxylase, C-terminal
Occurring in:
  1. Diaminopimelate decarboxylase 1, chloroplastic
IPR022657
Domain description: Orn/DAP/Arg decarboxylase 2, conserved site
Occurring in:
  1. Diaminopimelate decarboxylase 1, chloroplastic
IPR022653
Domain description: Orn/DAP/Arg decarboxylase 2, pyridoxal-phosphate binding site
Occurring in:
  1. Diaminopimelate decarboxylase 1, chloroplastic
IPR022644
Domain description: Orn/DAP/Arg decarboxylase 2, N-terminal
Occurring in:
  1. Diaminopimelate decarboxylase 1, chloroplastic
IPR022643
Domain description: Orn/DAP/Arg decarboxylase 2, C-terminal
Occurring in:
  1. Diaminopimelate decarboxylase 1, chloroplastic

Structure domains

CATH CATH domains
2.40.37.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Lyase, Ornithine Decarboxylase; Chain A, domain 1
Homology: Lyase, Ornithine Decarboxylase; Chain A, domain 1
Occurring in:
  1. Diaminopimelate decarboxylase 1, chloroplastic
The deposited structure of PDB entry 6n2a contains 2 copies of CATH domain 2.40.37.10 (Lyase, Ornithine Decarboxylase; Chain A, domain 1) in Diaminopimelate decarboxylase 1, chloroplastic. Showing 1 copy in chain A.
3.20.20.10
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Alanine racemase
Occurring in:
  1. Diaminopimelate decarboxylase 1, chloroplastic
The deposited structure of PDB entry 6n2a contains 2 copies of CATH domain 3.20.20.10 (TIM Barrel) in Diaminopimelate decarboxylase 1, chloroplastic. Showing 1 copy in chain A.

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