6n37

Electron Microscopy
3.8Å resolution

SegA-sym, conformation of TDP-43 low complexity domain segment A sym

Released:
Source organism: Homo sapiens
Primary publication:
Cryo-EM structures of four polymorphic TDP-43 amyloid cores.
OpenAccess logo Nat Struct Mol Biol 26 619-627 (2019)
PMID: 31235914
Related structures: EMD-9339

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo decamer (preferred)
PDBe Complex ID:
PDB-CPX-556010 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TAR DNA-binding protein 43 Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 50 amino acids
Theoretical weight: 5.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13148 (Residues: 311-360; Coverage: 12%)
Gene names: TARDBP, TDP43
Sequence domains: TAR DNA-binding protein 43, C-terminal

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.8Å
Relevant EMDB volumes: EMD-9339
Expression system: Escherichia coli BL21(DE3)