6n3a

Electron Microscopy
3.3Å resolution

SegA-long, conformation of TDP-43 low complexity domain segment A long

Released:
Source organism: Homo sapiens
Primary publication:
Cryo-EM structures of four polymorphic TDP-43 amyloid cores.
OpenAccess logo Nat Struct Mol Biol 26 619-627 (2019)
PMID: 31235914
Related structures: EMD-9349

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero icosamer (preferred)
PDBe Complex ID:
PDB-CPX-171561 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
TAR DNA-binding protein 43 Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 50 amino acids
Theoretical weight: 5.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13148 (Residues: 311-360; Coverage: 12%)
Gene names: TARDBP, TDP43
Sequence domains: TAR DNA-binding protein 43, C-terminal
TAR DNA-binding protein 43 Chains: K, L, M, N, O, P, Q, R, S, T
Molecule details ›
Chains: K, L, M, N, O, P, Q, R, S, T
Length: 10 amino acids
Theoretical weight: 1.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13148 (Residues: 338-347; Coverage: 2%)
Gene names: TARDBP, TDP43

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-9349
Expression systems:
  • Escherichia coli BL21(DE3)
  • Escherichia coli