› 6n9n

X-ray diffraction
3.3Å resolution

Crystal structure of murine GSDMD

Released:
DOI: 10.2210/pdb6n9n/pdb
PDB entry 6n9n coloured by chain, front view.
PDB entry 6n9n coloured by chain, side view.
PDB entry 6n9n coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Crystal Structures of the Full-Length Murine and Human Gasdermin D Reveal Mechanisms of Autoinhibition, Lipid Binding, and Oligomerization.
Liu Z, Wang C, Yang J, Zhou B, Yang R, Ramachandran R, Abbott DW, Xiao TS
Immunity 51 43-49.e4 (2019)
PMID: 31097341

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190069 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gasdermin-D Chains: A, B
Molecule details ›
Chains: A, B
Length: 488 amino acids
Theoretical weight: 53.38 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9D8T2 (Residues: 1-487; Coverage: 100%)
Gene names: Gsdmd, Gsdmdc1
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P21
Unit cell:
a: 66.42Å b: 86.84Å c: 83.54Å
α: 90° β: 95.27° γ: 90°
R-values:
R R work R free
0.264 0.261 0.321
Expression system: Escherichia coli

Quick links

Citations

63 review citations

Pyroptosis: mechanisms and diseases.
Yu et al. (2021)
62 more

10 mentions without citation

Gasdermin D in pyroptosis.
Burdette et al. (2021)
9 more