› 6ngg

X-ray diffraction
1.95Å resolution

Crystal structure of human CD160 V58M mutant

Released:
DOI: 10.2210/pdb6ngg/pdb
PDB entry 6ngg coloured by chain, front view.
PDB entry 6ngg coloured by chain, side view.
PDB entry 6ngg coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Basis of CD160:HVEM Recognition.
Liu W, Garrett SC, Fedorov EV, Ramagopal UA, Garforth SJ, Bonanno JB, Almo SC
Structure 27 1286-1295.e4 (2019)
PMID: 31230945

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132093 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CD160 antigen Chains: A, B
Molecule details ›
Chains: A, B
Length: 119 amino acids
Theoretical weight: 13.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli-Pichia pastoris shuttle vector pPpB1GAP_S
UniProt:
  • Canonical: O95971 (Residues: 27-144; Coverage: 75%)
Gene names: BY55, CD160

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P212121
Unit cell:
a: 44.662Å b: 54.06Å c: 92.604Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.217 0.27
Expression system: Escherichia coli-Pichia pastoris shuttle vector pPpB1GAP_S

Quick links

Citations

7 review citations

BTLA-HVEM Couple in Health and Diseases: Insights for Immunotherapy in Lung Cancer.
Demerlé et al. (2021)
6 more

1 mention without citation

Structural Basis of CD160:HVEM Recognition.
Liu et al. (2019)