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The structure of human liver pyruvate kinase, hLPYK-W527H

Source organism: Homo sapiens
Biochemical function: monosaccharide binding
Biological process: cellular response to epinephrine stimulus
Cellular component: extracellular exosome

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EC 2.7.1.40: Pyruvate kinase

Reaction catalysed:
ATP + pyruvate = ADP + phosphoenolpyruvate
Systematic name:
ATP:pyruvate 2-O-phosphotransferase
Alternative Name(s):
  • Phosphoenol transphosphorylase
  • Phosphoenolpyruvate kinase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF02887
Domain description: Pyruvate kinase, alpha/beta domain
Occurring in:
  1. Pyruvate kinase PKLR
The deposited structure of PDB entry 6nn5 contains 4 copies of Pfam domain PF02887 (Pyruvate kinase, alpha/beta domain) in Pyruvate kinase PKLR. Showing 1 copy in chain D.

PF00224
Domain description: Pyruvate kinase, barrel domain
Occurring in:
  1. Pyruvate kinase PKLR
The deposited structure of PDB entry 6nn5 contains 4 copies of Pfam domain PF00224 (Pyruvate kinase, barrel domain) in Pyruvate kinase PKLR. Showing 1 copy in chain D.

InterPro InterPro annotations
IPR001697
Domain description: Pyruvate kinase
Occurring in:
  1. Pyruvate kinase PKLR
IPR036918
Domain description: Pyruvate kinase, C-terminal domain superfamily
Occurring in:
  1. Pyruvate kinase PKLR
IPR015795
Domain description: Pyruvate kinase, C-terminal
Occurring in:
  1. Pyruvate kinase PKLR
IPR018209
Domain description: Pyruvate kinase, active site
Occurring in:
  1. Pyruvate kinase PKLR
IPR015806
Domain description: Pyruvate kinase, insert domain superfamily
Occurring in:
  1. Pyruvate kinase PKLR
IPR011037
Domain description: Pyruvate kinase-like, insert domain superfamily
Occurring in:
  1. Pyruvate kinase PKLR
IPR040442
Domain description: Pyruvate kinase-like domain superfamily
Occurring in:
  1. Pyruvate kinase PKLR
IPR015793
Domain description: Pyruvate kinase, barrel
Occurring in:
  1. Pyruvate kinase PKLR
IPR015813
Domain description: Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily
Occurring in:
  1. Pyruvate kinase PKLR

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