› 6no8

X-ray diffraction
2.38Å resolution

PIM1 in complex with Cpd9 ((R)-5-amino-N-(3-(4-aminoazepan-1-yl)-1H-pyrazol-4-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide)

Released:
DOI: 10.2210/pdb6no8/pdb
PDB entry 6no8 coloured by chain, front view.
PDB entry 6no8 coloured by chain, side view.
PDB entry 6no8 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Murray JM, wang X

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145753 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase pim-1 Chain: A
Molecule details ›
Chain: A
Length: 273 amino acids
Theoretical weight: 31.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P11309 (Residues: 33-305; Coverage: 87%)
Gene name: PIM1
Sequence domains: Protein kinase domain

Ligands and Environments

2 bound ligands:
Ligand KUY 1 x KUY
Ligand PO4 1 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P65
Unit cell:
a: 96.452Å b: 96.452Å c: 80.655Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.187 0.185 0.232
Expression system: Escherichia coli BL21(DE3)

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