› 6nrj

X-ray diffraction
1.65Å resolution

Function and Biology Details

Reaction catalysed: 
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140785 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Poly [ADP-ribose] polymerase 1, processed C-terminus Chain: A
Molecule details ›
Chain: A
Length: 271 amino acids
Theoretical weight: 30 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09874 (Residues: 788-1012; Coverage: 22%)
Gene names: ADPRT, PARP1, PPOL
Sequence domains: Poly(ADP-ribose) polymerase catalytic domain

Ligands and Environments

3 bound ligands:
Ligand KYJ 1 x KYJ
Ligand SO4 5 x SO4
Ligand DMS 2 x DMS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: I4122
Unit cell:
a: 94.465Å b: 94.465Å c: 137.627Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.169 0.168 0.191
Expression system: Escherichia coli

Quick links

Citations

2 review citations

PARP1: Structural insights and pharmacological targets for inhibition.
Spiegel et al. (2021)
1 more

2 mentions without citation

Benzimidazole and its derivatives as cancer therapeutics: The potential role from traditional to precision medicine.
Lee et al. (2023)
1 more