› 6nth

X-ray diffraction
2.42Å resolution

Crystal Structure of Recombinant Human Acetylcholinesterase Inhibited by (S) Stereoisomer of A-232

Released:
DOI: 10.2210/pdb6nth/pdb
PDB entry 6nth coloured by chain, front view.
PDB entry 6nth coloured by chain, side view.
PDB entry 6nth coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Bester SM, Guelta MA, Height JJ, Pegan SD

Function and Biology Details

Reaction catalysed: 
Acetylcholine + H(2)O = choline + acetate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149584 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Acetylcholinesterase Chains: A, B
Molecule details ›
Chains: A, B
Length: 542 amino acids
Theoretical weight: 59.45 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P22303 (Residues: 33-574; Coverage: 93%)
Gene name: ACHE
Sequence domains: Carboxylesterase family

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
2 bound ligands:
Ligand NAG 2 x NAG
Ligand L0S 2 x L0S
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P3121
Unit cell:
a: 105.646Å b: 105.646Å c: 324.221Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.15 0.149 0.173
Expression system: Homo sapiens

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