› 6nx4

Solution NMR

Structure of the C-terminal Helical Repeat Domain of Eukaryotic Elongation Factor 2 Kinase (eEF-2K)

Released:
DOI: 10.2210/pdb6nx4/pdb
PDB entry 6nx4 coloured by chain, ensemble of 20 models, front view.
PDB entry 6nx4 coloured by chain, ensemble of 20 models, side view.
PDB entry 6nx4 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution Structure of the Carboxy-Terminal Tandem Repeat Domain of Eukaryotic Elongation Factor 2 Kinase and Its Role in Substrate Recognition.
Piserchio A, Will N, Giles DH, Hajredini F, Dalby KN, Ghose R
J Mol Biol 431 2700-2717 (2019)
PMID: 31108082

Function and Biology Details

Reaction catalysed: 
ATP + [elongation factor 2] = ADP + [elongation factor 2] phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126268 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Eukaryotic elongation factor 2 kinase Chain: A
Molecule details ›
Chain: A
Length: 167 amino acids
Theoretical weight: 18.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O00418 (Residues: 562-725; Coverage: 23%)
Gene name: EEF2K

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 92%
Refinement method: molecular dynamics
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

eEF2K Inhibitor Design: The Progression of Exemplary Structure-Based Drug Design.
Klupt et al. (2023)
1 more

2 mentions without citation

Solution Structure of the Carboxy-Terminal Tandem Repeat Domain of Eukaryotic Elongation Factor 2 Kinase and Its Role in Substrate Recognition.
Piserchio et al. (2019)
1 more