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Structure of the human frataxin-bound iron-sulfur cluster assembly complex

Electron Microscopy
3.2Å resolution
PDB entry 6nzu coloured by chain, front view.
PDB entry 6nzu coloured by chain, side view.
PDB entry 6nzu coloured by chain, top view.
Source organisms:
Assembly composition:
hetero decamer (preferred)
Entry contents: 5 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero decamer
Accessible surface area: 62336.64 Å2
Buried surface area: 27520.82 Å2
Dissociation area: 5,194.04 Å2
Dissociation energy (ΔGdiss): -3.28 kcal/mol
Dissociation entropy (TΔSdiss): 48.52 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-167173

Macromolecules

Cysteine desulfurase
Chains: A, E
Length: 403 amino acids
Theoretical weight: 44.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
Gene names: HUSSY-08, NFS1, NIFS
InterPro:
Cysteine desulfurase in PDB entry 6nzu, assembly 1, front view.
Cysteine desulfurase in PDB entry 6nzu, assembly 1, side view.
Cysteine desulfurase in PDB entry 6nzu, assembly 1, top view.
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LYR motif-containing protein 4
Chains: B, F
Length: 92 amino acids
Theoretical weight: 10.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
Gene names: C6orf149, CGI-203, ISD11, LYRM4
InterPro:
LYR motif-containing protein 4 in PDB entry 6nzu, assembly 1, front view.
LYR motif-containing protein 4 in PDB entry 6nzu, assembly 1, side view.
LYR motif-containing protein 4 in PDB entry 6nzu, assembly 1, top view.
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Acyl carrier protein
Chains: C, G
Length: 74 amino acids
Theoretical weight: 8.25 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
InterPro:
Acyl carrier protein in PDB entry 6nzu, assembly 1, front view.
Acyl carrier protein in PDB entry 6nzu, assembly 1, side view.
Acyl carrier protein in PDB entry 6nzu, assembly 1, top view.
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Iron-sulfur cluster assembly enzyme ISCU
Chains: D, H
Length: 124 amino acids
Theoretical weight: 13.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
Gene names: ISCU, NIFUN
InterPro:
Iron-sulfur cluster assembly enzyme ISCU in PDB entry 6nzu, assembly 1, front view.
Iron-sulfur cluster assembly enzyme ISCU in PDB entry 6nzu, assembly 1, side view.
Iron-sulfur cluster assembly enzyme ISCU in PDB entry 6nzu, assembly 1, top view.
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Frataxin mature form
Chains: I, J
Length: 132 amino acids
Theoretical weight: 14.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
Gene names: FRDA, FXN, X25
InterPro:
Frataxin mature form in PDB entry 6nzu, assembly 1, front view.
Frataxin mature form in PDB entry 6nzu, assembly 1, side view.
Frataxin mature form in PDB entry 6nzu, assembly 1, top view.
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