6o20 › Citations

Structural insight into TRPV5 channel function and modulation.

Dang S, van Goor MK, Asarnow D, Wang Y, Julius D, Cheng Y, van der Wijst J
Proc Natl Acad Sci U S A 116 8869-8878 (2019)
Related entries: 6o1n, 6o1p, 6o1u

Cited: 54 times
EuropePMC logo PMID: 30975749

Abstract

TRPV5 (transient receptor potential vanilloid 5) is a unique calcium-selective TRP channel essential for calcium homeostasis. Unlike other TRPV channels, TRPV5 and its close homolog, TRPV6, do not exhibit thermosensitivity or ligand-dependent activation but are constitutively open at physiological membrane potentials and modulated by calmodulin (CaM) in a calcium-dependent manner. Here we report high-resolution electron cryomicroscopy structures of truncated and full-length TRPV5 in lipid nanodiscs, as well as of a TRPV5 W583A mutant and TRPV5 in complex with CaM. These structures highlight the mechanism of calcium regulation and reveal a flexible stoichiometry of CaM binding to TRPV5.

Reviews - 6o20 mentioned but not cited (4)

  1. Structural insights into the gating mechanisms of TRPV channels. Pumroy RA, Fluck EC, Ahmed T, Moiseenkova-Bell VY. Cell Calcium 87 102168 (2020)
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  4. Atomistic Insights of Calmodulin Gating of Complete Ion Channels. Núñez E, Muguruza-Montero A, Villarroel A. Int J Mol Sci 21 E1285 (2020)

Articles - 6o20 mentioned but not cited (3)

  1. Structural insight into TRPV5 channel function and modulation. Dang S, van Goor MK, Asarnow D, Wang Y, Julius D, Cheng Y, van der Wijst J. Proc Natl Acad Sci U S A 116 8869-8878 (2019)
  2. Anisotropic thermal expansion of La(n)(Ti,Fe)(n)O(3n + 2) (n = 5 and 6). Wölfel A, Dorscht P, Lichtenberg F, van Smaalen S. Acta Crystallogr B Struct Sci Cryst Eng Mater 69 137-144 (2013)
  3. Intracellular Helix-Loop-Helix Domain Modulates Inactivation Kinetics of Mammalian TRPV5 and TRPV6 Channels. Flores-Aldama L, Bustos D, Cabezas-Bratesco D, Gonzalez W, Brauchi SE. Int J Mol Sci 24 4470 (2023)


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  5. Structural Basis for High-Affinity Trapping of the NaV1.7 Channel in Its Resting State by Tarantula Toxin. Wisedchaisri G, Tonggu L, Gamal El-Din TM, McCord E, Zheng N, Catterall WA. Mol Cell 81 38-48.e4 (2021)
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  9. Inactivation-mimicking block of the epithelial calcium channel TRPV6. Bhardwaj R, Lindinger S, Neuberger A, Nadezhdin KD, Singh AK, Cunha MR, Derler I, Gyimesi G, Reymond JL, Hediger MA, Romanin C, Sobolevsky AI. Sci Adv 6 eabe1508 (2020)
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  16. Activity of the yeast vacuolar TRP channel TRPY1 is inhibited by Ca2+-calmodulin binding. Amini M, Chang Y, Wissenbach U, Flockerzi V, Schlenstedt G, Beck A. J Biol Chem 297 101126 (2021)
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  22. CaV channels reject signaling from a second CaM in eliciting Ca2+-dependent feedback regulation. Chakouri N, Diaz J, Yang PS, Ben-Johny M. J Biol Chem 295 14948-14962 (2020)
  23. Expression of Renal Vitamin D and Phosphatonin-Related Genes in a Sheep Model of Osteoporosis. Dittmer KE, Chernyavtseva A, Marshall JC, Cabrera D, Wolber FM, Kruger M. Animals (Basel) 12 67 (2021)
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  28. Molecular details of ruthenium red pore block in TRPV channels. Pumroy RA, De Jesús-Pérez JJ, Protopopova AD, Rocereta JA, Fluck EC, Fricke T, Lee BH, Rohacs T, Leffler A, Moiseenkova-Bell V. EMBO Rep 25 506-523 (2024)
  29. Bidirectional Allosteric Coupling between PIP2 Binding and the Pore of the Oncochannel TRPV6. Humer C, Radiskovic T, Horváti K, Lindinger S, Groschner K, Romanin C, Höglinger C. Int J Mol Sci 25 618 (2024)
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  33. Structural mechanism of TRPV5 inhibition by econazole. De Jesús-Pérez JJ, Gabrielle M, Raheem S, Fluck EC, Rohacs T, Moiseenkova-Bell VY. Structure 32 148-156.e5 (2024)
  34. miR-103a-3p Silencing Ameliorates Calcium Oxalate Deposition in Rat Kidney by Activating the UMOD/TRPV5 Axis. Cui Z, Li Y, Liu G, Jiang Y. Dis Markers 2022 2602717 (2022)


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