› 6o4p

X-ray diffraction
3.43Å resolution

The crystal structure of the interleukin 11 alpha receptor

Released:
DOI: 10.2210/pdb6o4p/pdb
PDB entry 6o4p coloured by chain, front view.
PDB entry 6o4p coloured by chain, side view.
PDB entry 6o4p coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of the extracellular domains of human interleukin 11α receptor reveals mechanisms of cytokine engagement.
Metcalfe RD, Aizel K, Zlatic CO, Nguyen PM, Morton CJ, Lio DS, Cheng HC, Dobson RCJ, Parker MW, Gooley PR, Putoczki TL, Griffin MDW
J Biol Chem 295 8285-8301 (2020)
PMID: 32332100

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172048 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Soluble interleukin-11 receptor subunit alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 349 amino acids
Theoretical weight: 38.21 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q14626 (Residues: 23-363; Coverage: 85%)
Gene name: IL11RA

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
2 bound ligands:
Ligand NAG 1 x NAG
Ligand SO4 11 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P6522
Unit cell:
a: 171.456Å b: 171.456Å c: 107.944Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.246 0.244 0.298
Expression system: Spodoptera frugiperda

Quick links

Citations

4 review citations

The Role of gp130 Cytokines in Tuberculosis.
Ritter et al. (2020)
3 more

8 mentions without citation

Structural Understanding of Interleukin 6 Family Cytokine Signaling and Targeted Therapies: Focus on Interleukin 11.
Metcalfe et al. (2020)
7 more