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Saccharomyces cerevisiae V-ATPase Stv1-V1VO State 1

Source organisms:
Biochemical function: proton-transporting ATPase activity, rotational mechanism
Biological process: proton transmembrane transport
Cellular component: membrane

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EC 7.1.2.2: H(+)-transporting two-sector ATPase

Reaction catalysed:
ATP + H(2)O + 4 H(+)(Side 1) = ADP + phosphate + 4 H(+)(Side 2)
Systematic name:
ATP phosphohydrolase (two-sector, H(+)-transporting)
Alternative Name(s):
  • ATP synthase
  • Bacterial Ca(2+)/Mg(2+) ATPase
  • Chloroplast ATPase
  • Coupling factors (F(o), F(1) and CF(1))
  • F(0)F(1)-ATPase
  • F(1)-ATPase
  • F(o)F(1)-ATPase
  • H(+)-transporting ATP synthase
  • H(+)-transporting ATPase
  • Mitochondrial ATPase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00137
Domain description: ATP synthase subunit C
Occurring in:
  1. V-type proton ATPase subunit c''
  2. V-type proton ATPase subunit c
  3. V-type proton ATPase subunit c'
The deposited structure of PDB entry 6o7v contains 2 copies of Pfam domain PF00137 (ATP synthase subunit C) in V-type proton ATPase subunit c''. Showing 2 copies in chain S [auth c].
The deposited structure of PDB entry 6o7v contains 16 copies of Pfam domain PF00137 (ATP synthase subunit C) in V-type proton ATPase subunit c. Showing 2 copies in chain Y [auth k].
The deposited structure of PDB entry 6o7v contains 2 copies of Pfam domain PF00137 (ATP synthase subunit C) in V-type proton ATPase subunit c'. Showing 2 copies in chain CA [auth o].

PF22919
Domain description: C-terminal domain of V and A type ATP synthase
Occurring in:
  1. V-type proton ATPase catalytic subunit A
  2. V-type proton ATPase subunit B

PF00006
Domain description: ATP synthase alpha/beta family, nucleotide-binding domain
Occurring in:
  1. V-type proton ATPase catalytic subunit A
  2. V-type proton ATPase subunit B
The deposited structure of PDB entry 6o7v contains 3 copies of Pfam domain PF00006 (ATP synthase alpha/beta family, nucleotide-binding domain) in V-type proton ATPase catalytic subunit A. Showing 1 copy in chain C [auth A].
The deposited structure of PDB entry 6o7v contains 3 copies of Pfam domain PF00006 (ATP synthase alpha/beta family, nucleotide-binding domain) in V-type proton ATPase subunit B. Showing 1 copy in chain D [auth B].

PF02874
Domain description: ATP synthase alpha/beta family, beta-barrel domain
Occurring in:
  1. V-type proton ATPase catalytic subunit A
  2. V-type proton ATPase subunit B
The deposited structure of PDB entry 6o7v contains 3 copies of Pfam domain PF02874 (ATP synthase alpha/beta family, beta-barrel domain) in V-type proton ATPase catalytic subunit A. Showing 1 copy in chain C [auth A].
The deposited structure of PDB entry 6o7v contains 3 copies of Pfam domain PF02874 (ATP synthase alpha/beta family, beta-barrel domain) in V-type proton ATPase subunit B. Showing 1 copy in chain D [auth B].

PF03179
Domain description: Vacuolar (H+)-ATPase G subunit
Occurring in:
  1. V-type proton ATPase subunit G
The deposited structure of PDB entry 6o7v contains 3 copies of Pfam domain PF03179 (Vacuolar (H+)-ATPase G subunit) in V-type proton ATPase subunit G. Showing 1 copy in chain M [auth H].

PF01991
Domain description: ATP synthase (E/31 kDa) subunit
Occurring in:
  1. V-type proton ATPase subunit E
The deposited structure of PDB entry 6o7v contains 3 copies of Pfam domain PF01991 (ATP synthase (E/31 kDa) subunit) in V-type proton ATPase subunit E. Showing 1 copy in chain N [auth G].

PF16886
Domain description: ATPsynthase alpha/beta subunit N-term extension
Occurring in:
  1. V-type proton ATPase catalytic subunit A
The deposited structure of PDB entry 6o7v contains 3 copies of Pfam domain PF16886 (ATPsynthase alpha/beta subunit N-term extension) in V-type proton ATPase catalytic subunit A. Showing 1 copy in chain C [auth A].

PF05493
Domain description: ATP synthase subunit H
Occurring in:
  1. V-type proton ATPase subunit e
The deposited structure of PDB entry 6o7v contains 1 copy of Pfam domain PF05493 (ATP synthase subunit H ) in V-type proton ATPase subunit e. Showing 1 copy in chain DA [auth e].

PF01992
Domain description: ATP synthase (C/AC39) subunit
Occurring in:
  1. V-type proton ATPase subunit d
The deposited structure of PDB entry 6o7v contains 1 copy of Pfam domain PF01992 (ATP synthase (C/AC39) subunit) in V-type proton ATPase subunit d. Showing 1 copy in chain T [auth d].

PF20520
Domain description: V0 complex accessory subunit Ac45/VOA1 transmembrane domain
Occurring in:
  1. V0 assembly protein 1
The deposited structure of PDB entry 6o7v contains 1 copy of Pfam domain PF20520 (V0 complex accessory subunit Ac45/VOA1 transmembrane domain) in V0 assembly protein 1. Showing 1 copy in chain R [auth b].

PF01496
Domain description: V-type ATPase 116kDa subunit family
Occurring in:
  1. V-type proton ATPase subunit a, Golgi isoform
The deposited structure of PDB entry 6o7v contains 1 copy of Pfam domain PF01496 (V-type ATPase 116kDa subunit family ) in V-type proton ATPase subunit a, Golgi isoform. Showing 1 copy in chain Q [auth a].

PF11698
Domain description: V-ATPase subunit H
Occurring in:
  1. V-type proton ATPase subunit H
The deposited structure of PDB entry 6o7v contains 1 copy of Pfam domain PF11698 (V-ATPase subunit H) in V-type proton ATPase subunit H. Showing 1 copy in chain K [auth P].

PF03224
Domain description: V-ATPase subunit H
Occurring in:
  1. V-type proton ATPase subunit H
The deposited structure of PDB entry 6o7v contains 1 copy of Pfam domain PF03224 (V-ATPase subunit H) in V-type proton ATPase subunit H. Showing 1 copy in chain K [auth P].

PF03223
Domain description: V-ATPase subunit C
Occurring in:
  1. V-type proton ATPase subunit C
The deposited structure of PDB entry 6o7v contains 1 copy of Pfam domain PF03223 (V-ATPase subunit C) in V-type proton ATPase subunit C. Showing 1 copy in chain L [auth O].

PF01990
Domain description: ATP synthase (F/14-kDa) subunit
Occurring in:
  1. V-type proton ATPase subunit F
The deposited structure of PDB entry 6o7v contains 1 copy of Pfam domain PF01990 (ATP synthase (F/14-kDa) subunit) in V-type proton ATPase subunit F. Showing 1 copy in chain B [auth N].

PF01813
Domain description: ATP synthase subunit D
Occurring in:
  1. V-type proton ATPase subunit D
The deposited structure of PDB entry 6o7v contains 1 copy of Pfam domain PF01813 (ATP synthase subunit D ) in V-type proton ATPase subunit D. Showing 1 copy in chain A [auth M].

InterPro InterPro annotations
IPR000245
Domain description: V-ATPase proteolipid subunit
Occurring in:
  1. V-type proton ATPase subunit c''
  2. V-type proton ATPase subunit c
  3. V-type proton ATPase subunit c'
IPR035921
Domain description: F/V-ATP synthase subunit C superfamily
Occurring in:
  1. V-type proton ATPase subunit c''
  2. V-type proton ATPase subunit c
  3. V-type proton ATPase subunit c'
IPR002379
Domain description: V-ATPase proteolipid subunit C-like domain
Occurring in:
  1. V-type proton ATPase subunit c''
  2. V-type proton ATPase subunit c
  3. V-type proton ATPase subunit c'
IPR011555
Domain description: V-ATPase proteolipid subunit C, eukaryotic
Occurring in:
  1. V-type proton ATPase subunit c
  2. V-type proton ATPase subunit c'
IPR005124
Domain description: Vacuolar (H+)-ATPase G subunit
Occurring in:
  1. V-type proton ATPase subunit G
IPR002842
Domain description: V-type ATPase subunit E
Occurring in:
  1. V-type proton ATPase subunit E
IPR022879
Domain description: V-type ATP synthase regulatory subunit B/beta
Occurring in:
  1. V-type proton ATPase subunit B
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. V-type proton ATPase catalytic subunit A
  2. V-type proton ATPase subunit B
IPR020003
Domain description: ATPase, alpha/beta subunit, nucleotide-binding domain, active site
Occurring in:
  1. V-type proton ATPase catalytic subunit A
  2. V-type proton ATPase subunit B
IPR000194
Domain description: ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain
Occurring in:
  1. V-type proton ATPase catalytic subunit A
  2. V-type proton ATPase subunit B
IPR004100
Domain description: ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain
Occurring in:
  1. V-type proton ATPase catalytic subunit A
  2. V-type proton ATPase subunit B
IPR022878
Domain description: V-type ATP synthase catalytic alpha chain
Occurring in:
  1. V-type proton ATPase catalytic subunit A
IPR004908
Domain description: ATPase, V1 complex, subunit H
Occurring in:
  1. V-type proton ATPase subunit H
IPR004907
Domain description: ATPase, V1 complex, subunit C
Occurring in:
  1. V-type proton ATPase subunit C
IPR002699
Domain description: ATPase, V1 complex, subunit D
Occurring in:
  1. V-type proton ATPase subunit D
IPR038495
Domain description: V-type ATPase subunit E, C-terminal domain superfamily
Occurring in:
  1. V-type proton ATPase subunit E
IPR005723
Domain description: ATPase, V1 complex, subunit B
Occurring in:
  1. V-type proton ATPase subunit B
IPR024034
Domain description: ATPase, F1/V1 complex, beta/alpha subunit, C-terminal
Occurring in:
  1. V-type proton ATPase catalytic subunit A
IPR031686
Domain description: ATPsynthase alpha/beta subunit, N-terminal extension
Occurring in:
  1. V-type proton ATPase catalytic subunit A
IPR005725
Domain description: ATPase, V1 complex, subunit A
Occurring in:
  1. V-type proton ATPase catalytic subunit A
IPR036121
Domain description: ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily
Occurring in:
  1. V-type proton ATPase catalytic subunit A
IPR023366
Domain description: ATP synthase subunit alpha, N-terminal domain-like superfamily
Occurring in:
  1. V-type proton ATPase catalytic subunit A
IPR008389
Domain description: ATPase, V0 complex, subunit e1/e2
Occurring in:
  1. V-type proton ATPase subunit e
IPR035067
Domain description: V-type ATPase subunit C/d
Occurring in:
  1. V-type proton ATPase subunit d
IPR016727
Domain description: ATPase, V0 complex, subunit d
Occurring in:
  1. V-type proton ATPase subunit d
IPR002490
Domain description: V-type ATPase, V0 complex, 116kDa subunit family
Occurring in:
  1. V-type proton ATPase subunit a, Golgi isoform
IPR036906
Domain description: ATPase, V1 complex, subunit F superfamily
Occurring in:
  1. V-type proton ATPase subunit F
IPR026770
Domain description: Ribonuclease kappa
Occurring in:
  1. V-type proton ATPase subunit f
IPR044911
Domain description: V-type ATP synthase c/d subunit, domain 3 superfamily
Occurring in:
  1. V-type proton ATPase subunit d
IPR002843
Domain description: ATPase, V0 complex, c/d subunit
Occurring in:
  1. V-type proton ATPase subunit d
IPR036079
Domain description: V-type ATP synthase subunit c/d subunit superfamily
Occurring in:
  1. V-type proton ATPase subunit d
IPR046756
Domain description: V-type proton ATPase subunit S1/VOA1, transmembrane domain
Occurring in:
  1. V0 assembly protein 1
IPR026028
Domain description: ATPase, V0 complex, subunit 116kDa, eukaryotic
Occurring in:
  1. V-type proton ATPase subunit a, Golgi isoform
IPR038497
Domain description: ATPase, V1 complex, subunit H, C-terminal domain superfamily
Occurring in:
  1. V-type proton ATPase subunit H
IPR011987
Domain description: ATPase, V1 complex, subunit H, C-terminal
Occurring in:
  1. V-type proton ATPase subunit H
IPR016024
Domain description: Armadillo-type fold
Occurring in:
  1. V-type proton ATPase subunit H
IPR011989
Domain description: Armadillo-like helical
Occurring in:
  1. V-type proton ATPase subunit H
IPR036132
Domain description: Vacuolar ATP synthase subunit C superfamily
Occurring in:
  1. V-type proton ATPase subunit C
IPR008218
Domain description: ATPase, V1 complex, subunit F
Occurring in:
  1. V-type proton ATPase subunit F
IPR005772
Domain description: ATPase, V1 complex, subunit F, eukaryotic
Occurring in:
  1. V-type proton ATPase subunit F

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