6oi3

X-ray diffraction
1.66Å resolution

Crystal structure of human WDR5 in complex with monomethyl H3R2 peptide

Released:
Model geometry
Fit model/data

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-158496 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
WD repeat-containing protein 5 Chain: A
Molecule details ›
Chain: A
Length: 313 amino acids
Theoretical weight: 34.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61964 (Residues: 22-334; Coverage: 94%)
Gene names: BIG3, WDR5
Sequence domains: WD domain, G-beta repeat
Histone H3.3C Chain: B
Molecule details ›
Chain: B
Length: 24 amino acids
Theoretical weight: 2.52 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q6NXT2 (Residues: 2-22; Coverage: 16%)
Gene names: H3-5, H3F3C

Ligands and Environments

2 bound ligands:
1 modified residue:

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 31-ID
Spacegroup: C2221
Unit cell:
a: 78.294Å b: 98.632Å c: 80.265Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.173 0.172 0.202
Expression systems:
  • Escherichia coli
  • Not provided