› 6oi5

X-ray diffraction
2.81Å resolution

Crystal structure of human Sulfide Quinone Oxidoreductase

Released:
DOI: 10.2210/pdb6oi5/pdb
PDB entry 6oi5 coloured by chain, front view.
PDB entry 6oi5 coloured by chain, side view.
PDB entry 6oi5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A Catalytic Trisulfide in Human Sulfide Quinone Oxidoreductase Catalyzes Coenzyme A Persulfide Synthesis and Inhibits Butyrate Oxidation.
Landry AP, Moon S, Kim H, Yadav PK, Guha A, Cho US, Banerjee R
Cell Chem Biol 26 1515-1525.e4 (2019)
PMID: 31591036

Function and Biology Details

Reaction catalysed: 
Hydrogen sulfide + glutathione + a quinone = S-sulfanylglutathione + a quinol
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195376 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sulfide:quinone oxidoreductase, mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 418 amino acids
Theoretical weight: 47.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y6N5 (Residues: 42-450; Coverage: 91%)
Gene names: CGI-44, SQOR, SQRDL
Sequence domains: Pyridine nucleotide-disulphide oxidoreductase

Ligands and Environments

1 bound ligand:
Ligand FAD 2 x FAD
1 modified residue:
Ligand CSS 2 x CSS

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P212121
Unit cell:
a: 76.729Å b: 110.424Å c: 132.124Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.189 0.256
Expression system: Escherichia coli

Quick links

Citations

11 review citations

Cysteine metabolic circuitries: druggable targets in cancer.
Bonifácio et al. (2021)
10 more

4 mentions without citation

Hydrogen Sulfide Oxidation by Sulfide Quinone Oxidoreductase.
Landry et al. (2021)
3 more