› 6oks

Electron Microscopy
4.2Å resolution

CDTb Double Heptamer Long Form Mask 1 Modeled from Cryo-EM Map Reconstructed using C7 Symmetry

Released:
DOI: 10.2210/pdb6oks/pdb
PDB entry 6oks coloured by chain, front view.
PDB entry 6oks coloured by chain, side view.
PDB entry 6oks coloured by chain, top view.
Source organism: Clostridioides difficile
Primary publication:
Structural insights into the transition of Clostridioides difficile binary toxin from prepore to pore.
Anderson DM, Sheedlo MJ, Jensen JL, Lacy DB
OpenAccess logo Nat Microbiol 5 102-107 (2020)
PMID: 31712627
Related structures: EMD-20103

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetradecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-108612 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
PA14 domain-containing protein Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N
Length: 876 amino acids
Theoretical weight: 98.92 KDa
Source organism: Clostridioides difficile
Expression system: Escherichia coli
UniProt:
  • Canonical: A8DS70 (Residues: 1-876; Coverage: 100%)
Gene name: cdtB
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.2Å
Relevant EMDB volumes: EMD-20103
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Clostridioides difficile toxins: mechanisms of action and antitoxin therapeutics.
Kordus et al. (2022)
9 more

1 mention without citation

Structural insights into the transition of Clostridioides difficile binary toxin from prepore to pore.
Anderson et al. (2020)