› 6omt

X-ray diffraction
2.05Å resolution

HIV-1 capsid hexamer R18D mutant

Released:
DOI: 10.2210/pdb6omt/pdb
PDB entry 6omt coloured by chain, front view.
PDB entry 6omt coloured by chain, side view.
PDB entry 6omt coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
FEZ1 Is Recruited to a Conserved Cofactor Site on Capsid to Promote HIV-1 Trafficking.
Huang PT, Summers BJ, Xu C, Perilla JR, Malikov V, Naghavi MH, Xiong Y
Cell Rep 28 2373-2385.e7 (2019)
PMID: 31422020

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146190 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Capsid protein p24 Chain: A
Molecule details ›
Chain: A
Length: 232 amino acids
Theoretical weight: 25.55 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P12493 (Residues: 132-363; Coverage: 46%)
Gene name: gag
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P6
Unit cell:
a: 90.662Å b: 90.662Å c: 56.576Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.183 0.181 0.221
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

26 review citations

HIV-1 Maturation: Lessons Learned from Inhibitors.
Kleinpeter et al. (2020)
25 more

14 mentions without citation

Molecular Origins of Functional Diversity in Benzylisoquinoline Alkaloid Methyltransferases.
Morris et al. (2019)
13 more